We previously demonstrated that short-term dietary interventions can significantly alter both the immune system and the microbiome10. However, the functional consequences of these changes, especially in patients with autoimmune diseases, remain unexplored. To address this gap, we will design innovative dietary intervention trials to explore these critical questions. Building on our previous work, we will employ a bulk multi-omics approach and integrate advanced single-cell multi-omics techniques, including RNA-seq, ATAC-seq, and proteomics, to achieve a comprehensive understanding of immune responses. We also strive to collect and analyze tissue samples from the skin and gut to gain deeper insights. Additionally, we will utilize the results from our mouse studies to design improved trials in humans. These studies will involve participants in both controlled environments, similar to our previous study, as well as at-home settings, allowing for a larger, more genetically diverse cohort. The studies will focus on three key objectives:
- Evaluating Functional Consequences: Assess the impact of dietary interventions on the human immune system by monitoring immune responses to immunological challenges, such as a vaccine.
- Investigating Dysregulated Immune Systems: Examine how patients with chronic inflammatory diseases respond to dietary interventions within a controlled environment.
- Exploring Cancer Treatment: In the long term, we aim to investigate the potential benefits of controlled dietary interventions for patients undergoing cancer treatment.
These objectives will inform the development of precision nutrition therapies tailored to individual genetic profiles, with the potential to prevent and ameliorate disease etiology and prevent disease onset and recurrence.